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Home - Products - Chromatin/Epigenetic - Histone Demethylase - T-3775440 hydrochloride

T-3775440 hydrochloride

CAS No. 1422535-52-1

T-3775440 hydrochloride ( T 3775440;T3775440 )

Catalog No. M11774 CAS No. 1422535-52-1

A novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    T-3775440 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM.
  • Description
    A novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM; displays high selectivity for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B); disrupts the interaction between LSD1 and growth factor-independent 1B (GFI1B) in leukemia cell lines, exhibites significant antitumor efficacy in AEL and AMKL xenograft models.
  • Synonyms
    T 3775440;T3775440
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    Histone Demethylase
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1422535-52-1
  • Formula Weight
    346.86
  • Molecular Formula
    C18H23ClN4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 30.18 mg/mL 87.01 mM
  • SMILES
    CN1C=C(C=N1)C(=O)NC2=CC=C(C=C2)C3CC3NCC4CC4.Cl
  • Chemical Name
    N-(4-((1S,2R)-2-((cyclopropylmethyl)amino)cyclopropyl)phenyl)-1-methyl-1H-pyrazole-4-carboxamide hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Takagi S, et al. Cancer Res. 2017 Jun 30. pii: canres.3502.2016.
2. Ishikawa Y, et al. Mol Cancer Ther. 2017 Feb;16(2):273-284.
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